Clastogenic effects of synthetic food dyes using Salmonella typhimurium and Allium cepa test systems
نویسندگان
چکیده
The present study embodied the mutagenic/genotoxic potential of two most commonly used synthetic food dyes, viz., sky blue and orange red, employing Ames Salmonella histidine reversion point mutation assay and Allium cepa root chromosomal aberration assay. It was observed that sky blue and orange red dyes showed 6-fold increase in TA100 strain from the spontaneous count, whereas they showed non-mutagenic response in TA98 tester strain of S. typhimurium. In the chromosomal aberration assay, sky blue and orange red dyes induced 50.90 and 64.48% total aberrant cells, respectively.
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Received 16/7/2012 Accepted 21/1/2013 (005793) 1 Núcleo de Pesquisa Aplicada a Saúde e ao Meio-ambiente, Laboratório de Citogenética Vegetal e Animal, Universidade Federal do Piauí – UFPI, Campus Senador Helvídio Nunes de Barros, Rua Cícero Duarte, 940, Bairro Junco, CEP 64600-000, Picos, PI, Brasil, e-mail: [email protected] *Corresponding author Citotoxicity of food dyes Sunset Yellow ...
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